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Suicidal behavior has been reported in very rare cases in patients treated with hydroxychloroquine.

Convulsionsseizuresextrapyramidal symptomsabnormal body movementsrestlessnessshakingor stiffnesssigns of a severe skin reaction such as blisteringpeelinga rash covering a large area of the bodya rash that spreads quicklyor a rash combined with fever or discomfort signs of a serious allergic reactione.gabdominal crampsdifficulty breathingnausea and vomitingor swelling of the face and throatthoughts of suicide or self-harm.

This medication is also usedusually with other medicationsto treat certain auto-immune diseaseslupusrheumatoid arthritiswhen other medications have not worked or cannot be usedIt belongs to a class of medications known as disease-modifying antirheumatic drugsDMARDsIt can reduce skin problems in lupus and prevent swelling/pain in arthritisthough it is not known exactly how the drug works.

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methotrexate combined use of methotrexate with plaquenil has not been studied and may increase the incidence of adverse effects.

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